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Authors: Dr. Barry Sears

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Centers for Disease Control.
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Schenk S, Saberi M, and Olefsky JM. “Insulin sensitivity: modulation by nutrients and inflammation.” J Clin Invest 118: 2992–3002 (2008)

Sears B.
The Zone
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Sears B.
The Anti-Aging Zone
. Regan Books. New York, NY (1999)

Sears B.
The Anti-Inflammation Zone
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Sears B.
Toxic Fat
. Thomas Nelson. Nashville, TN (2008)

Tabues G. “Prosperity’s Plague.” Science 325: 256–260 (2009)

Xu A, Wang Y, Xu JY, Stejskal D, Tam S, Zhang J, Wat NM, Wong WK, and Lam KS. “Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome.” Clin Chem 52: 405–413 (2006)

CHAPTER 3. THE ZONE DIET: ANTI-INFLAMMATORY NUTRITION MADE SIMPLE

Bell SJ and Sears B. “Low-glycemic-load diets: impact on obesity and chronic diseases.” Crit Rev Food Sci Nutr 43: 357–377 (2003)

Berg JM, Tymoczko JL, and Stryer L.
Biochemistry, 5th edition
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Bierhaus A, Stern DM, and Nawroth PP. “RAGE in inflammation: a new therapeutic target?”Curr Opin Investig Drugs 7: 985–991 (2006)

Curtiss LK. “Reversing atherosclerosis?” N Engl J Med 360: 1144–1146 (2009)

Davidenko O, Darcel N, Fromentin G, and Tome D. “Control of protein and energy intake - brain mechanisms.” Eur J Clin Nutr 67: 455–461 (2013)

Ebbeling CB, Swain JF, Feldman HA, Wong WW, Hachey DL, Garcia-Lago E, and Ludwig DS. “Effects of dietary composition on energy expenditure during weight-loss maintenance.” JAMA 307: 2627–2634 (2012)

Holvoet P. “Oxidized LDL and coronary heart disease.” Acta Cardiol 59: 479–484 (2004)

Ishigaki Y, Oka Y, and Katagiri H. “Circulating oxidized LDL: a biomarker and a pathogenic factor.” Curr Opin Lipidol 20: 363–369 (2009)

Johnston CS, Tjonn SL, Swan PD, White A, Hutchins H, and Sears B. “Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets.” Am J Clin Nutr 83: 1055–1061 (2006)

Joslin Diabetes Research Center.
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and Diabetes (2007)

Kawabata T, Hirota S, Hirayama T, Adachi N, Hagiwara C, Iwama N, Kamachi K, Araki E, Kawashima H, and Kiso Y. “Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women.” Prostaglandins Leukot Essent Fatty Acids 84: 131–137 (2011)

Kuipers RS, Luxwolda MF, Dijck-Brouwer DA, Eaton SB, Crawford MA, Cordain L, and Muskiet FA. “Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet.” Br J Nutr 104: 1666–1687 (2010)

Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, and Roberts SB. “High glycemic index foods, overeating, and obesity.” Pediatrics 103: E26 (1999)

McLaughlin T, Reaven G, Abbasi F, Lamendola C, Saad M, Waters D, Simon J, and Krauss RM. “Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease?” Am J Cardiol 96: 399–404 (2005)

Pereira MA, Swain J, Goldfine AB, Rifai N, and Ludwig DS. “Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss.” JAMA 292: 2482–2490 (2004)

Pittas AG, Roberts SB, Das SK, Gilhooly CH, Saltzman E, Golden J, Stark PC, and Greenberg AS. “The effects of the dietary glycemic load on type 2 diabetes risk factors during weight loss.” Obesity 14: 2200–2209 (2006)

Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, and Schmidt AM. “Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation.” Glycobiology 15: 16R–28R (2005)

Sears B.
The Zone
. Regan Books. New York, NY (1995)

Sears B.
Mastering the Zone.
Regan Books. New York, NY (1997)

Sears B.
Zone Perfect Meals in Minutes.
Regan Books. New York, NY (1998)

Sears B.
The OmegaRx Zone
. Regan Books. New York, NY (2002)

Sears B and Sears L.
Zone Meals in Seconds.
Regan Books. New York, NY (2005)

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Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K. and Shirato K. “Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.” Lancet 369: 1090–1098 (2007)

CHAPTER 4: FACTS AND FICTION ABOUT THE MEDITERRANEAN DIET

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Boccardi V, Esposito A, Rizzo MR, Marfella R, Barbieri M, and Paolisso G. “Mediterranean diet, telomere maintenance and health status among elderly.” PLoS ONE 8: e62781 (2013)

Buckland G, Bach A, and Serra-Majem L. “Obesity and the Mediterranean diet: a systematic review of observational and intervention studies.” Obes 9: 582–593 (2008)

Buckland G, Agudo A, Travier N, Huerta JM, Cirera L, Tormo MJ, Navarro C, Chirlaque MD, Moreno-Iribas C, Ardanaz E, Barricarte A, Etxeberria J, Marin P, Quirós JR, Redondo ML, Larrañaga N, Amiano P, Dorronsoro M, Arriola L, Basterretxea M, Sanchez MJ, Molina E, and González CA. “Adherence to the Mediterranean diet reduces mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain).” Br J Nutr 106: 1581–1591 (2011)

Dedoussis GV, Kanoni S, Mariani E, Cattini L, Herbein G, Fulop T, Varin A, Rink L, Jajte J, Monti D, Marcellini F, Malavolta M, and Mocchegiani E. “Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study.” Clin Chem Lab Med 46: 990–996 (2008)

de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P, and Delaye J. “Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease.” Lancet 343: 1454–1559 (1994)

de Lorgeril M, Salen P, Martin JL, Monjaud I, Boucher P, and Mamelle N. “Mediterranean dietary pattern in a randomized trial: prolonged survival and possible reduced cancer rate.” Arch Intern Med 158: 1181–1187 (1998)

de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, and Mamelle N. “Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study.” Circulation 99: 779–785 (1999)

de Lorgeril M and Salen P. “Mediterranean diet in secondary prevention of CHD.” Public Health Nutr 14: 2333–2337 (2011)

de Lorgeril M. “Mediterranean diet and cardiovascular disease: historical perspective and latest evidence.” Curr Athosclero Rep 15: 370 (2013)

Djuric Z. “The Mediterranean diet: effects on proteins that mediate fatty acid metabolism in the colon.” Nutr Rev 69: 730–744 (2011)

Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X,
Basora J, Muñoz MA, Sorlí JV, Martínez JA, and Martínez-González MA. “Primary prevention of cardiovascular disease with a Mediterranean diet.” N Engl J Med 368: 1279–1290 (2013)

Feart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, Scarmeas N, and Barberger-Gateau P. “Adherence to a Mediterranean diet, cognitive decline, and risk of dementia.” JAMA 302: 638–648 (2009)

Feart C, Samieri C, and Barberger-Gateau P. “Mediterranean diet and cognitive function in older adults.” Curr Opin Clin Nutr Metab Care 13: 14–18 (2010)

Feart C, Torres MJ, Samieri C, Jutand MA, Peuchant E, Simopoulos AP, and Barberger-Gateau P. “Adherence to a Mediterranean diet and plasma fatty acids: data from the Bordeaux sample of the Three-City study.” Br J Nutr 106: 149–158 (2011)

Feart C, Torres MJ, Samieri C, Jutand MA, Peuchant E, Simopoulos AP, and Barberger-Gateau P. “Potential benefits of adherence to the Mediterranean diet on cognitive health.” Proc Nutr Soc 72: 140–152 (2013)

Fragopoulou E, Panagiotakos DB, Pitsavos C, Tampourlou M, Chrysohoou C, Nomikos T, Antonopoulou S, and Stefanadis C. “The association between adherence to the Mediterranean diet and adiponectin levels among healthy adults: the ATTICA study.” J Nutr Biochem 21: 285–289 (2010)

Gardener S, Gu Y, Rainey-Smith SR, Keogh JB, Clifton PM, Mathieson SL, Taddei K, Mondal A, Ward VK, Scarmeas N, Barnes M, Ellis KA, Head R, Masters CL, Ames D, Macaulay SL, Rowe CC, Szoeke C, and Martins RN. “Adherence to a Mediterranean diet and Alzheimer’s disease risk in an Australian population.” Transl Psychiatry 2: e164 (2012)

Hoevenaar-Blom MP, Nooyens AC, Kromhout D, Spijkerman AM, Beulens JW, van der Schouw YT, Bueno-de-Mesquita B, and Verschuren WM. “Mediterranean style diet and 12-year incidence of cardiovascular diseases: the EPIC-NL cohort study.” PLoS ONE 7: e45458 (2012)

Itsiopoulos C, Brazionis L, Kaimakamis M, Cameron M, Best JD, O’Dea K, Rowley K. “Can the Mediterranean diet lower HbA1c in type 2 diabetes? Results from a randomized cross-over study.” Nutr Metab Cardiovasc Dis 21: 740–747 (2011)

Jones JL, Comperatore M, Barona J, Calle MC, Andersen C, McIntosh M, Najm W, Lerman RH, and Fernandez ML. “A Mediterranean-style, low-glycemic-load diet decreases atherogenic lipoproteins and reduces lipoprotein (a) and oxidized low-density lipoprotein in women with metabolic syndrome.” Metabolism 61: 366–372 (2012)

Kafatos A, Diacatou A, Voukiklaris G, Nikolakakis N, Vlachonikolis J, Kounali D, Mamalakis G, Dontas AS. “Heart disease risk-factor status and dietary changes in the Cretan population over the past 30 y: the Seven Countries Study.” Am J Clin Nutr 65: 1882–1886 (1997)

Kesse-Guyot E, Andreeva VA, Lassale C, Ferry M, Jeandel C, Hercberg S, and Galan P. “Mediterranean diet and cognitive function: a French study.” Am J Clin Nutr 97: 369–376 (2013)

Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, and Llewellyn DJ. “Mediterranean diet, cognitive function, and dementia: a systematic review.” Epidemiology 24: 479–489 (2013)

Martínez-González MA, de la Fuente-Arrillaga C, Nunez-Cordoba JM,
Basterra-Gortari FJ, Beunza JJ, Vazquez Z, Benito S, Tortosa A, and Bes-Rastrollo M. “Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study.” BMJ 336: 1348–1351 (2008)

Menotti A, Keys A, Kromhout D, Blackburn H, Aravanis C, Bloemberg B, Buzina R, Dontas A, Fidanza F, and Giampaoli S. “Inter-cohort differences in coronary heart disease mortality in the 25-year follow-up of the seven countries study.” Eur J Epidemiol 9: 527–536 (1993)

Mitrou PN, Kipnis V, Thiébaut AC, Reedy J, Subar AF, Wirfält E, Flood A, Mouw T, Hollenbeck AR, Leitzmann MF, and Schatzkin A. “Mediterranean dietary pattern and prediction of all-cause mortality in a US population: results from the NIH-AARP Diet and Health Study.” Arch Intern Med 167: 2461–2468 (2007)

Pitsavos C, Panagiotakos DB, Tzima N, Chrysohoou C, Economou M, Zampelas A, and Stefanadis C. “Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: the ATTICA study.” Am J Clin Nutr 82: 694–699 (2005)

Perez-Lopez FR, Chedraui P, Haya J, and Cuadros JL. “Effects of the Mediterranean diet on longevity and age-related morbid conditions.” Maturitas 64: 67–79 (2009)

Salas-Salvadó J, Bulló M, Babio N, Martínez-González MÁ, Ibarrola-Jurado N, Basora J, Estruch R, Covas MI, Corella D, Arós F, Ruiz-Gutiérrez V, and Ros E. “Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial.” Diabetes Care 34: 14–19 (2011)

Renaud S and de Lorgeril M. “Wine, alcohol, platelets, and the French paradox for coronary heart disease.” Lancet 339: 1523–1526 (1992)

Rossi M, Turati F, Lagiou P, Trichopoulos D, Augustin LS, La Vecchia C, and Trichopoulu. “Mediterranean diet and glycaemic load in relation to incidence of type 2 diabetes.” Diabetologia 56: 2405–13 (2013)

Samieri C, Okereke OI, E Devore E, and Grodstein F. “Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women.” J Nutr 143: 493–499 (2013)

Samieri C, Grodstein F, Rosner BA, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, and Okereke OI. “Mediterranean diet and cognitive function in older age.” Epidemiology 24: 490–499 (2013)

Scarmeas N, Luchsinger JA, Mayeux R, and Stern Y. “Mediterranean diet and Alzheimer disease mortality.” Neurology. 69: 1084–1093 (2007)

Scarmeas N, Luchsinger JA, Stern Y, Gu Y, He J, DeCarli C, Brown T, and Brickman AM. “Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease.” Ann Neurol 69: 257–268 (2011)

BOOK: The Mediterranean Zone
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